Publications

P R Jenkins, K Menear, P Barraclough and M Nobbs. " An Intramolecular Diels-Alder Approach to Forskolin". J. Chem. Soc. Commun., 1984, 1423.

P R Jenkins, K Menear, P Magnus and C Walker. "Mechanistic Rationalisation of an Apparently Non-Stereospecific Intramolecular Diels-Alder Reaction". Tetrahedron Letters., 1986, 27, 651.

Kump, Wilhelm; Menear, Keith Allan, Preparation of Rifamycin Derivatives for Treatment of Hyperlipidemia and Arteriosclerosis. Eur. Pat. Appl., EP 314624 A1 890503.

Taylor, Peter William; Matthews, Ian Timothy William; Lowrie, Jane Isabelle; Menear, Keith Allan; Kump, Wilhelm. New Rifamycin Derivatives. Eur. Pat. Appl., EP 314041 A1 890503.

K Menear, P W Taylor, I T W Matthews and E Tomlinson. UK Patent Case 14/87

K Menear, K E Dunnet, J C Gibson, E F Kimble, I T W Mathews and P W Taylor. X International symposium on Drugs affecting Lipid Metabolism; Abstract, November 1989, Houston , Texas.

K Menear, K E Dunnet, J C Gibson, E F Kimble, J G Hastewell, H G Eichler, W Kump and P W Taylor. "Hypolipideamic Activity of a Novel Acyclic Ansamycin Derivative". Arzneim.-Forsch./Drug Res. 1992, 42, 1125.

K Menear, K E Dunnet, J G Hastewell, H G Eichler and P W Taylor. "Studies on the Uptake of Low Molecular Weight Momomeric Tris-galactosyl Conjugates by the Rat Liver". Biochem. Pharmacol. 1992, 44, 2117.

K Menear, D Patel, V Clay, C Howes and P W Taylor. "A Novel Approach to the Site Specific Delivery of Potential HMG-CoA Reductase Inhibitors". Bioorganicand Medicinal Chemistry Letters. 1992, 2, 285.

Brundish, Derek Edward; Le Grand, Darren Mark; Menear, Keith Allan; Allen, Mark Christopher; Butler, Walker, Clive Victor; Tetrahydroquinoline Inhibitors of Trypsin and Thrombin. GB2312674 A

Brundish, Derek Edward; Brown, Lyndon Nigel; Le Grand, Darren Mark; Menear, Keith Allan; Smith, Garrick Paul; Allen, Mark Christopher; Butler, Paul Ian; Cockroft, Xiao-Ling; Matthews, Ian Timothy William; Walker, Clive Victor; Preparation of pyridylsulfonyl amino acid amide derivatives as thrombin inhibitors. WO 9746553 A1 971211

Keith A Menear, Progress Towards the Discovery of Orally Active Thrombin Inhibitors. Current Medicinal Chemistry. (1998), 5, 457.

John Ambler, Emma Baker, Lyndon Brown, Paul Butler, Karen Dunnet, Darren Le Grand, Diana Janus, Darryl Jones, Keith Menear*, Mark Mercer, Garrick Smith, Mark Talbot. The Discovery of Orally Available Thrombin Inhibitors : Studies Towards the Optimisation of CGH1668. Bioorg. Med. Chem. Lett. (1998), 8(24), 3583-3588.

John Ambler, Emma Baker, Lyndon Brown, Paul Butler, Karen Dunnet, Darren Le Grand, Diana Janus, Darryl Jones, Keith Menear*, Mark Mercer, Garrick Smith, Mark Talbot The Discovery of Orally Available Thrombin Inhibitors : Studies Towards the Identification of a Potent, Selective and Bioavailable Thrombin Inhibitors. Bioorg. Med. Chem. Lett. (1999), 9(5), 737.

Keith Menear, The Potential for Protein Kinase Inhibitors in Respiratory Disease. Abstract, Conquering Airway Inflammation in the 21st Century. 14-16th September 1998, National Heart and Lung Institute, London.

Xiao-Ling Cockcroft^*, Trevor Howe, Keith Menear and Pascal Furet.The Features of a General Pharmacophore Model for ATP-Competitive Protein Kinase Inhibitors: the Prospects for Selective Inhibitor Design. Abstract : 15-17th September 1998, 1st International Conference on the Inhibitors of Protein Kinases, Warsaw

Darren Baldock, Brent Graham, Mohammed Akhlaq, Carol Jones and Keith Menear. Expression, Purification And Characterisation of P72 Syk. Third European Symposium of the Protein Society, Germany, September 19-22th, 1999.

John Ambler, David Bentley, Lyndon Brown, Karen Dunnet, Dave Farr, Darren Le Grand*, Diana Janus, Keith Menear, Mark Mercer, Mark Talbot and Bernard Wathey. The Discovery of Orally Available Thrombin Inhibitors : Optimisation of the P1 Pharmacophore. Bioorg. Med. Chem. Lett. (1999), 9, 1103.

John Ambler, Lyndon Brown, Xiao-Ling Cockcroft, Markus Grütter, Judy Hayler, Diana Janus, Darryl Jones, Peter Kane, Keith Menear*, John Priestle, Garrick Smith, Mark Talbot, Clive V Walker & Bernard Wathey. Optimisation of the P2 Pharmacophore in a Series of Thrombin Inhibitors : Ion-dipole Interactions with Lysine 60G. Bioorg. Med. Chem. Lett. (1999), 9, 1317-1322.

Baettig U, Menear K, Talbot M, Kane P, Pay G, Walker C, LeGrand D, Matthews I, Wathey B, Smith G, Brown, L, Brundish D, Dunnet K, Butler K, Ambler J, Arnold R, Tweed M, Mitchelson A, Butler P, Jones D, Cockcroft X-L, Allen M, Janus D, Hayler J, Baker E, Mercer M. “The discovery of orally active thrombin inhibitors”. Poster and abstract for 10th RSC-SCI Medicinal Chemistry Symposium, Cambridge, 5-8 September 1999.

Menear K. “Direct thrombin inhibitors : Curent status and future perspectives”. Expert Opinion on Investigational Drugs. 1999, 8(9), 1373-1384.

Darren Baldock, Brent Graham, Mohammed Akhlaq, Patrick Graff, Carol E. Jones and Keith Menear. Purification and Characterization of Human Syk Produced Using a Baculovirus Expression System. Protein Expression and Purification. 2000, 18, 86–94

Judy Hayler, Peter D. Kane, Darren LeGrand, Florence Lugrin, Keith Menear, Richard Price, Mark Allen, Xiaoling Cockcroft, John Ambler, Keith Butler, Karren Dunnet, Andrew Mitchelson, Mark Talbot, Morris Tweed and Nicholas Wills. Thrombin Inhibitors : The Introduction of In Vivo Efficacy and Oral Bioavailability into Benzthiazolylalanine Inhibitors. Bioorganic & Medicinal Chemistry Letters 10 (2000) 1567-1570

Lach-Trifilieff, Estelle; Menear, Keith; Schweighoffer, Edina; Tybulewicz, Victor L. J.; Walker, Christoph. Syk-deficient eosinophils show normal interleukin-5-mediated differentiation, maturation, and survival but no longer respond to FcR activation. Blood (2000), 96(7), 2506-2510.

Collingwood, Stephen Paul; Hayler, Judy; Le Grand, Darren Mark; Mattes, Henri; Menear, Keith Allan; Walker, Clive Victor; Cockcroft, Xiao-ling. Purine derivatives inhibitors of tyrosine protein kinase syk. PCT Int. Appl. (2001), 70 pp. WO0109134 A1

Smith, Graeme, Cameron, Murray; Martin, Niall, Morrison, Barr; Jackson, Stephen, Philip; O'connor, Mark, James Lau, Alan, Yin, Kai, Cockcroft, Xiao-Ling, Fan; Matthews, Ian, Timothy Williams. Menear, Keith; Rigoreau, Laurent, Hummersone, Marc; Griffin, Roger. Pyranones Useful As ATM Inhibitors WO 03/070726

Martin, Niall, Morrison, Barr; Smith, Graeme, Jackson, Stephen, Philip. Loh, Vincent, M., Junior; Cockcroft, Xiao-Ling, Fan, Matthews, Ian, Timothy, Williams; Menear, Keith, Allan; Kerrigan, Frank; Ashworth, Alan; WO 2004/080976 Phthalazinone Derivatives

Smith, Graeme Cameron Murray; Martin, Niall Morrison Barr; Cockcroft, Xiao-ling Fan; Matthews, Ian Timothy Williams; Menear, Keith Allan; Rigoreau, Laurent Jean Martin; Hummersone, Marc Geoffrey; Griffin, Roger John. Preparation of aminopyrones for use in pharmaceutical compositions as ATM kinase inhibitors. WO 2005016919

Martin, Niall Morrison Barr; Smith, Graeme Cameron; Jackson, Stephen Philip; Loh, Vincent M., Jr.; Cockcroft, Xiao-Ling Fan; Matthews, Ian Timothy Williams; Menear, Keith Allan; Kerrigan, Frank; Ashworth, Alan. Preparation of phthalazinones as PARP inhibitors. US 20050059663

Vincent M. Loh, Jr., Xiao-ling Cockcroft, Krystyna J. Dillon, Lesley Dixon, Jan Drzewiecki, Penny J. Eversley, Sylvie Gomez, Janet Hoare, Frank Kerrigan, Ian T.W. Matthews, Keith A. Menear, Niall M.B. Martin, Roger F. Newton, Jane Paul, Graeme C.M. Smith, Julia Vile and Alan J. Whittle^. Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerise. Bioorg. Med. Chem. Lett. (2005), 15 (19), 2235-2238.

Xiao-ling Cockcroft, Krystyna J. Dillon, Lesley Dixon, Jan Drzewiecki, Vincent M. Loh, Jr., Frank Kerrigan, Keith A. Menear, Niall M.B. Martin and Graeme C.M. Smith.^. Phthalazinones. Part 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerise. Bioorg. Med. Chem. Lett. (2006), 16 (4), 1040-1044.

Javaid, Muhammad Hashim; Smith, Graeme Cameron Murray; Martin, Niall Morrison Barr; Gomez, Sylvie; Loh, Vincent Ming Lai. Jr.; Cockcroft, Xiao-Ling Fan; Forte, Stefano; Menear, Keith Allan; Matthews, Ian Timothy William. 4-Heteroarylmethyl-substituted phthalazinone derivatives as PARP-1 inhibitors, their preparation, pharmaceutical compositions, and use in therapy. WO2006021801 A1

Smith, Greame Cameron Murray; Martin, Niall Morrison Barr; Menear, Keith Allan; Hummersone, Marc Geoffrey; Rigoreau, Laurent Jean Martin; Griffin, Roger John; Golding, Bernard Thomas; Newell, David Richard; Calvert, Hilary Alan; Curtin, Nicola Jane; Hardcastle, Ian Robert; Saravanan, Kappusamy. Preparation of 8-(dibenzothiophen-4-yl)chromen-4-ones as DNA-PK inhibitors. WO2006032869 A1

Javaid, Muhammad Hashim; Smith, Graeme Cameron Murray; Martin, Niall Morrison Barr; Gomez, Sylvie; Loh, Vincent Junior Ming Lai; Cockcroft, Xiao-Ling Fan; Menear, Keith Allan. Preparation of 2-alkoxybenzenecarboxamides as poly(ADP-ribose)polymerase (PARP) inhibitors for the treatment of cancer. US2006135770 A1

Hummersone, Marc Geoffrey; Menear, Keith Allan; Rigoreau, Laurent Jean Martin; Smith, Graeme Cameron Murray; Martin, Niall Morrison Barr; Griffin, Roger John. Preparation of dibenzothiophene-derivative kinase ATM inhibitors. US 2006178361 A1

Hummersone, Marc Geoffrey; Gomez, Sylvie; Menear, Keith Allan; Cockcroft, Xiao-Ling Fan; Smith, Graeme Cameron Murray. Preparation of methylenehydrazinotriazinediamine derivatives and related analogs as inhibitors of mTOR. WO 2006090167 A2

Hummersone, Marc Geoffrey; Gomez, Sylvie; Menear, Keith Allan; Cockcroft, Xiao-Ling Fan; Edwards, Peter; Loh, Vincent Junior Ming Lai; Smith, Graeme Cameron Murray. Preparation of pyridopyrimidine diamines as inhibitors of mTOR. WO 2006090169 A1

Smith, Graeme Cameron Murray; Martin, Niall Morrison Barr; Cockcroft, Xiao-Ling Fan; Menear, Keith Allan; Hummersone, Marc Geoffrey; Griffin, Roger John; Frigerio, Mark; Golding, Bernard Thomas; Hardcastle, Ian Robert; Newell, David Richard; Calvert, Hilary Alan; Curtin, Nicola Jane; Desage-El Murr, Marine. Dna-pk inhibitors. WO 2006109084 A1

Smith, Graeme Cameron Murray; Martin, Niall Morrison Barr; Hummersone, Marc Geoffrey; Menear, Keith Allan; Cockcroft, Xiao-Ling Fan; Frigerio, Mark; Griffin, Roger John; Golding, Bernard Thomas; Hardcastle, Ian Robert; Newell, David Richard; Calvert, Hilary Alan; Curtin, Nicola Jane; Saravanan, Kappusamy; Desage-El Murr, Marine. Dna-pk inhibitors. WO 2006109081 A1

Smith, Graeme Cameron Murray; Martin, Niall Morrison Barr; Slade, Andrew James; Menear, Keith Allan; Hummersone, Marc Geoffrey; Cockcroft, Xiao-Ling Fan; Matthews, Ian Timothy William; Rigoreau, Laurent Jean Martin; Griffin, Roger John; Newell, David Richard; Curtin, Nicola Jane. ATM protein inhibitor. US 2007049588

Hollick, Jonathan J.; Rigoreau, Laurent J. M.; Cano-Soumillac, Celine; Cockcroft, Xiaoling; Curtin, Nicola J.; Frigerio, Mark; Golding, Bernard T.; Guiard, Sophie; Hardcastle, Ian R.; Hickson, Ian; Hummersone, Marc G.; Menear, Keith A.; Martin, Niall M. B.; Matthews, Ian; Newell, David R.; Ord, Rachel; Richardson, Caroline J.; Smith, Graeme C. M.; Griffin, Roger J. Pyranone, Thiopyranone, and Pyridone Inhibitors of Phosphatidylinositol 3-Kinase Related Kinases. Structure-Activity Relationships for DNA-Dependent Protein Kinase Inhibition, and Identification of the First Potent and Selective Inhibitor of the Ataxia Telangiectasia Mutated Kinase. Journal of Medicinal Chemistry (2007), 50(8), 1958-1972

Javaid, Muhammad Hashim; Menear, Keith Allan; Gomez, Sylvie; Hummersone, Marc Geoffrey; Martin, Niall Morrisson Barr; Smith, Graeme Cameron Murray; Cockcroft, Xiao-Ling Fan. Preparation of 4-heteroarylmethyl phthalazinone derivatives as PARP inhibitors. WO 2007045877 A1

Hummersone, Marc Geoffrey; Gomez, Sylvie; Menear, Keith Allan; Smith, Graeme Cameron Murray; Malagu, Karine; Duggan, Heather Mary Ellen; Cockcroft, Xiao-Ling Fan; Hermann, Gesine Johanna. Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. WO 2007060404 A1

Smith, Graeme Cameron Murray. Martin, Niall Morrison Barr. Menear, Keith, Allan. Hummersone, Marc, Geoffrey. Griffin, Roger. Rigoreau, Laurent Jean. ATM Inhibitors EP01848712 A1

Javaid, Muhammad Hashim; Menear, Keith Allan; Gomez, Sylvie; Martin, Niall Morrisson Barr; Cockcroft, Xiao-Ling Fan.PARP Inhibitors WO2007144652

Javaid, Muhammad Hashim; Menear, Keith Allan; Gomez, Sylvie; Martin, Niall Morrisson Barr; Cockcroft, Xiao-Ling Fan 2-Oxybenzamide Derivatives As PARP Inhibitors WO2007144639

Javaid, Muhammad Hashim; Menear, Keith Allan; Martin, Niall Morrisson Barr; Cockcroft, Xiao-Ling Fan 2 -Oxyheteroarylamide Derivatives As PARP Inhibitors WO2007144637

Hummersone, Marc Geoffrey; Gomez, Sylvie; Menear, Keith Allan; Smith, Graeme Cameron Murray; Cockcroft, Xiao-Ling Fan; Edwards, Peter. Loh, Vincent. 2,4-Diamino-Pyridopyrimidine Derivatives and Their Use as mTOR Inhibitors EP01871377

Smith, Graeme Cameron Murray. Gomez, Sylvie. Menear, Keith Allan. Cockcroft, Xiao-Ling Fan. Hummersone, Marc Geoffrey. Hydrazinomethyl, Hydrazonomethyl and 5-Membered Heterocylic Compounds which act as mTOR Inhibitors and their use as Anti Cancer Agents EP01877388

Martin, Niall, Morrisson, Barr; Smith, Graeme, Cameron, Murray; Duggan, Heather, Mary, Ellen; Leroux, Frederic Georges Marie; Menear, Keith, Allan; Malagu, Karine 2-Methylmorpholine Pyrido-, Pyrazo- and Pyrimido-Pyrimidine Derivatives as mTor Inhibitors WO2008023161

Menear KA, Adcock C, Boulter R, Cockcroft XL, Copsey L, Cranston A, Dillon KJ, Drzewiecki J, Garman S, Gomez S, Javaid H, Kerrigan F, Knights C, Lau A, Loh VM Jr, Matthews IT, Moore S, O'Connor MJ, Smith GC, Martin NM. 4-[3-(4-cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: a novel bioavailable inhibitor of poly(ADP-ribose) polymerase-1. J Med Chem. 2008, 51(20):6581-91.

Desage-El Murr M, Cano C, Golding BT, Hardcastle IR, Hummersome M, Frigerio M, Curtin NJ, Menear K, Richardson C, Smith GC, Griffin RJ. 8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK). Bioorg Med Chem Lett. 2008;18(17):4885-90.

Menear KA, Adcock C, Alonso FC, Blackburn K, Copsey L, Drzewiecki J, Fundo A, Le Gall A, Gomez S, Javaid H, Lence CF, Martin NM, Mydlowski C, Smith GC. Novel alkoxybenzamide inhibitors of poly(ADP-ribose) polymerase. Bioorg Med Chem Lett. 2008;18(14):3942-5.

Menear, Keith, Allan; Ottridge, Anthony, Oeter; .Londesbrough, Derek, John; Hallett, Michael, Raymond; Mullholland, Keith, Raymond; Pittam, John, David; Laffan, David, Dermot, Patrick; Ashworth, Ian, Woodward; Jones, Martin, Francis; Cherryman, Janette, Helen. Polymorphic form of 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one (WO/2008/047082).

Menear, Keith Allan; Hummersone, Marc Geoffrey; Gomez, Sylvie; Javaid, Muhammad Hashim; Martin, Niall Morrison Barr; Kerrigan, Frank; Phthalazinone derivatives WO/2008/114023

Menear, Keith, Allan; Hummersone, Marc, Geoffrey; Gomez, Sylvie; Javaid, Muhammad, Hashim; Martin, Niall, Morrison, Barr; Phthalazinone derivatives and their use as medicament to treat cancer, WO/2008/122810

Javaid, Muhammad, Hashim; Menear, Keith, Allan; Martin, Niall, Morrison, Barr; Smith, Graeme, Cameron, Murray; Rudge, David, Alan; Roberts, Craig, Anthony; Phthalazinone derivatives as inhibitors of parp-1, WO/2009/004356

Frigerio, Mark; Hummersone, Marc Geoffrey; Menear, Keith Allan; Bailey, Christine Sarah; Duggan, Heather Mary Ellen; Gomez, Sylvie; Martin, Niall Morrison Barr; DNA-PK Inhibitors, WO/2009/010761

Javaid, Muhammad, Hashim; Menear, Keith, Allan; Martin, Niall, Morrison, Barr; Phthalazinone Derivatives, WO/2009/034326

Yasuchika Yamaguchi, Keith Menear, Nissim-Claude Cohen, Robert Maha, Frédéric Cumin, Christian Schnell, Jeanette M. Wood, Jürgen Maibaum. The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues

of aliskiren are in vitro potent inhibitors of the human aspartyl protease rennin. Bioorg Med Chem Lett. 2009 15;19(16):4863-7

Golding SE,Rosenberg E, Valerie N, Hussaini I, Frigerio M, Cockcroft XL, Chong WY, Rigoreau L, Hummersone M, Menear KA, O’Connor MJ, Povirk LF, vanMeter T, Valerie K.Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT, and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009; 8(10):2894-902

Keith A. Menear, Sylvie Gomez, Karine Malagu, Christine Bailey, Kristel Blackburn, Xiao-Ling Cockcroft, Sally Ewen , Alexandra Fundo, Armelle Le Gall, Gesine Hermann, Luisa Sebastian, Mihiro Sunose, Thomas Presnot, Eleanor Torode , Ian Hickson , Niall M. B. Martin, Graeme C. M. Smith , Kurt G. Pike. Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR. Bioorg Med Chem Lett. 2009 15;19(20):5898-901.

Karine Malagu, Heather Duggan, Keith Menear, Marc Hummersone, Sylvie Gomez, Christine Bailey, Peter Edwards, Jan Drzewiecki, Frédéric Leroux, Mar Jimenez Quesada, Gesine Hermann, Stephanie Maine, Carrie-Anne Molyneaux, Armelle Le Gall, James Pullen, Ian Hickson, Lisa Smith, Sharon Maguire, Niall Martin, Graeme Smith, Martin Pass. The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5950-3.

Cano C, Barbeau OR, Bailey C, Cockcroft XL, Curtin NJ, Duggan H, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Knights C, Menear KA, Newell DR, Richardson CJ, Smith GC, Spittle B, Griffin RJ. DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype. J Med Chem. 2010;53(24):8498-507.

Chresta CM, Davies BR, Hickson I, Harding T, Cosulich S, Critchlow SE, Vincent JP, Ellston R, Jones D, Sini P, James D, Howard Z, Dudley P, Hughes G, Smith L, Maguire S, Hummersone M, Malagu K, Menear K, Jenkins R, Jacobsen M, Smith GC, Guichard S, Pass M. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.

Cancer Res. 2010;70(1):288-98.

Clapham KM, Bardos J, Finlay MR, Golding BT, Griffen EJ, Griffin RJ, Hardcastle IR, Menear KA, Ting A, Turner P, Young GL, Cano C. DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain. Bioorg Med Chem Lett. 2011 Feb 1;21(3):966-70.

Munck JM, Batey MA, Zhao Y, Jenkins H, Richardson CJ, Cano C, Tavecchio M, Barbeau J, Bardos J, Cornell L, Griffin RJ, Menear K, Slade A, Thommes P, Martin NM, Newell DR, Smith GC, Curtin NJ. Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K.Mol Cancer Ther. 2012 Aug;11(8):1789-98.

Pike KG, Malagu K, Hummersone MG, Menear KA, Duggan HM, Gomez S, Martin NM, Ruston L, Pass SL, Pass M. Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1212-6.

Cano C, Saravanan K, Bailey C, Bardos J, Curtin NJ, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Menear KA, Newell DR, Richardson CJ, Shea K, Smith GC, Thommes P, Ting A, Griffin RJ. 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity. J Med Chem. 2013 Aug 22;56(16):6386-401.

Call us on 07788908182 or contact us directly via our contact form.